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primary polyclonal rabbit anti sclerostin antibody  (Bioss)


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    Bioss primary polyclonal rabbit anti sclerostin antibody
    Immunohistochemistry with fluorescence (IHC-F) following removal from the host at 2 and 4 weeks treated (SclAb) and untreated. Human osteogenesis imperfecta (OI) implants were dual IHC-F stained to probe for the presence of Osterix (Osx; green) and human mitochondria (hMito; red) (A-D) and on serial sections, <t>Sclerostin</t> (yellow) and hMito (red) (E-H). In all cases, hMito was used to indicate donor derived cells and Osx or sclerostin primary antibody (validated sensitivity to both mouse and human antigens) were used to probe all instances of expression (both host and donor). Zoomed insets (1) depict lining cells expressing Osx (A-D) and osteocytes expressing sclerostin (E-H). Representative Hematoxylin and Eosin stained bone acquired at baseline (I). Images were acquired at 40x (50 μm scale bar). DAPI= nuclear stain (blue). Panel represents data from one OI patient (OI 6, Type III/IV OI) who yielded cortical-derived bone samples (I), hematoxylin and eosin (H&E) stained implant acquired at 20x with a 250 μm scale bar.
    Primary Polyclonal Rabbit Anti Sclerostin Antibody, supplied by Bioss, used in various techniques. Bioz Stars score: 93/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/primary polyclonal rabbit anti sclerostin antibody/product/Bioss
    Average 93 stars, based on 7 article reviews
    primary polyclonal rabbit anti sclerostin antibody - by Bioz Stars, 2026-02
    93/100 stars

    Images

    1) Product Images from "A Xenograft Model to Evaluate the Bone Forming Effects of Sclerostin Antibody in Human Bone Derived from Pediatric Osteogenesis Imperfecta Patients"

    Article Title: A Xenograft Model to Evaluate the Bone Forming Effects of Sclerostin Antibody in Human Bone Derived from Pediatric Osteogenesis Imperfecta Patients

    Journal: Bone

    doi: 10.1016/j.bone.2019.115118

    Immunohistochemistry with fluorescence (IHC-F) following removal from the host at 2 and 4 weeks treated (SclAb) and untreated. Human osteogenesis imperfecta (OI) implants were dual IHC-F stained to probe for the presence of Osterix (Osx; green) and human mitochondria (hMito; red) (A-D) and on serial sections, Sclerostin (yellow) and hMito (red) (E-H). In all cases, hMito was used to indicate donor derived cells and Osx or sclerostin primary antibody (validated sensitivity to both mouse and human antigens) were used to probe all instances of expression (both host and donor). Zoomed insets (1) depict lining cells expressing Osx (A-D) and osteocytes expressing sclerostin (E-H). Representative Hematoxylin and Eosin stained bone acquired at baseline (I). Images were acquired at 40x (50 μm scale bar). DAPI= nuclear stain (blue). Panel represents data from one OI patient (OI 6, Type III/IV OI) who yielded cortical-derived bone samples (I), hematoxylin and eosin (H&E) stained implant acquired at 20x with a 250 μm scale bar.
    Figure Legend Snippet: Immunohistochemistry with fluorescence (IHC-F) following removal from the host at 2 and 4 weeks treated (SclAb) and untreated. Human osteogenesis imperfecta (OI) implants were dual IHC-F stained to probe for the presence of Osterix (Osx; green) and human mitochondria (hMito; red) (A-D) and on serial sections, Sclerostin (yellow) and hMito (red) (E-H). In all cases, hMito was used to indicate donor derived cells and Osx or sclerostin primary antibody (validated sensitivity to both mouse and human antigens) were used to probe all instances of expression (both host and donor). Zoomed insets (1) depict lining cells expressing Osx (A-D) and osteocytes expressing sclerostin (E-H). Representative Hematoxylin and Eosin stained bone acquired at baseline (I). Images were acquired at 40x (50 μm scale bar). DAPI= nuclear stain (blue). Panel represents data from one OI patient (OI 6, Type III/IV OI) who yielded cortical-derived bone samples (I), hematoxylin and eosin (H&E) stained implant acquired at 20x with a 250 μm scale bar.

    Techniques Used: Immunohistochemistry, Fluorescence, Staining, Derivative Assay, Expressing



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    primary polyclonal rabbit anti sclerostin antibody  (Bioss)
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    Bioss primary polyclonal rabbit anti sclerostin antibody
    Immunohistochemistry with fluorescence (IHC-F) following removal from the host at 2 and 4 weeks treated (SclAb) and untreated. Human osteogenesis imperfecta (OI) implants were dual IHC-F stained to probe for the presence of Osterix (Osx; green) and human mitochondria (hMito; red) (A-D) and on serial sections, <t>Sclerostin</t> (yellow) and hMito (red) (E-H). In all cases, hMito was used to indicate donor derived cells and Osx or sclerostin primary antibody (validated sensitivity to both mouse and human antigens) were used to probe all instances of expression (both host and donor). Zoomed insets (1) depict lining cells expressing Osx (A-D) and osteocytes expressing sclerostin (E-H). Representative Hematoxylin and Eosin stained bone acquired at baseline (I). Images were acquired at 40x (50 μm scale bar). DAPI= nuclear stain (blue). Panel represents data from one OI patient (OI 6, Type III/IV OI) who yielded cortical-derived bone samples (I), hematoxylin and eosin (H&E) stained implant acquired at 20x with a 250 μm scale bar.
    Primary Polyclonal Rabbit Anti Sclerostin Antibody, supplied by Bioss, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/primary polyclonal rabbit anti sclerostin antibody/product/Bioss
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    primary polyclonal rabbit anti sclerostin antibody - by Bioz Stars, 2026-02
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    Immunohistochemistry with fluorescence (IHC-F) following removal from the host at 2 and 4 weeks treated (SclAb) and untreated. Human osteogenesis imperfecta (OI) implants were dual IHC-F stained to probe for the presence of Osterix (Osx; green) and human mitochondria (hMito; red) (A-D) and on serial sections, <t>Sclerostin</t> (yellow) and hMito (red) (E-H). In all cases, hMito was used to indicate donor derived cells and Osx or sclerostin primary antibody (validated sensitivity to both mouse and human antigens) were used to probe all instances of expression (both host and donor). Zoomed insets (1) depict lining cells expressing Osx (A-D) and osteocytes expressing sclerostin (E-H). Representative Hematoxylin and Eosin stained bone acquired at baseline (I). Images were acquired at 40x (50 μm scale bar). DAPI= nuclear stain (blue). Panel represents data from one OI patient (OI 6, Type III/IV OI) who yielded cortical-derived bone samples (I), hematoxylin and eosin (H&E) stained implant acquired at 20x with a 250 μm scale bar.
    Sclerostin Primary Antibody Polyclonal Rabbit Antibody Against Sclerostin, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sclerostin primary antibody polyclonal rabbit antibody against sclerostin/product/Danaher Inc
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    sclerostin primary antibody polyclonal rabbit antibody against sclerostin - by Bioz Stars, 2026-02
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    Image Search Results


    Immunohistochemistry with fluorescence (IHC-F) following removal from the host at 2 and 4 weeks treated (SclAb) and untreated. Human osteogenesis imperfecta (OI) implants were dual IHC-F stained to probe for the presence of Osterix (Osx; green) and human mitochondria (hMito; red) (A-D) and on serial sections, Sclerostin (yellow) and hMito (red) (E-H). In all cases, hMito was used to indicate donor derived cells and Osx or sclerostin primary antibody (validated sensitivity to both mouse and human antigens) were used to probe all instances of expression (both host and donor). Zoomed insets (1) depict lining cells expressing Osx (A-D) and osteocytes expressing sclerostin (E-H). Representative Hematoxylin and Eosin stained bone acquired at baseline (I). Images were acquired at 40x (50 μm scale bar). DAPI= nuclear stain (blue). Panel represents data from one OI patient (OI 6, Type III/IV OI) who yielded cortical-derived bone samples (I), hematoxylin and eosin (H&E) stained implant acquired at 20x with a 250 μm scale bar.

    Journal: Bone

    Article Title: A Xenograft Model to Evaluate the Bone Forming Effects of Sclerostin Antibody in Human Bone Derived from Pediatric Osteogenesis Imperfecta Patients

    doi: 10.1016/j.bone.2019.115118

    Figure Lengend Snippet: Immunohistochemistry with fluorescence (IHC-F) following removal from the host at 2 and 4 weeks treated (SclAb) and untreated. Human osteogenesis imperfecta (OI) implants were dual IHC-F stained to probe for the presence of Osterix (Osx; green) and human mitochondria (hMito; red) (A-D) and on serial sections, Sclerostin (yellow) and hMito (red) (E-H). In all cases, hMito was used to indicate donor derived cells and Osx or sclerostin primary antibody (validated sensitivity to both mouse and human antigens) were used to probe all instances of expression (both host and donor). Zoomed insets (1) depict lining cells expressing Osx (A-D) and osteocytes expressing sclerostin (E-H). Representative Hematoxylin and Eosin stained bone acquired at baseline (I). Images were acquired at 40x (50 μm scale bar). DAPI= nuclear stain (blue). Panel represents data from one OI patient (OI 6, Type III/IV OI) who yielded cortical-derived bone samples (I), hematoxylin and eosin (H&E) stained implant acquired at 20x with a 250 μm scale bar.

    Article Snippet: Sections were incubated with the primary anti-hMito antibody (MAB1273, EMD Millipore) at a 1:200 dilution and either a primary polyclonal rabbit anti-Osx antibody (ab22552, Abcam; 1:400) or primary polyclonal rabbit anti-sclerostin antibody (bs-10200r, Bioss; 1:200) overnight at 4°C.

    Techniques: Immunohistochemistry, Fluorescence, Staining, Derivative Assay, Expressing